Cognitive & mood
Dihexa
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide · small molecule · nootropic
An extremely potent nootropic candidate in rodent studies — one of the most experimental compounds here, with essentially no human safety or efficacy data.
Reference status
Editorial research · independent review pending · 3 claims graded
What it is
Dihexa was developed from angiotensin-IV-related research and showed striking synaptic-growth and memory effects in rodent studies at very low doses, generating significant nootropic-community interest.
It is important to be blunt: dihexa has essentially no published human trial data of any kind. Everything known about its effects and safety comes from animal and cell studies. This is one of the largest evidence gaps in this entire library.
The science, graded
What’s claimed — and how strong the evidence behind each claim actually is.
“Promotes new synapse formation and memory”
Striking rodent-study results at very low doses; no human data exists to confirm this translates.
Claim-level citation mapping is in progress.
“Effective orally at microgram doses”
Based on animal pharmacokinetics; human oral bioavailability claims are unverified.
Claim-level citation mapping is in progress.
“Safe for regular human use”
Unknown. There is essentially no human safety data to support or refute this.
Claim-level citation mapping is in progress.
Legal and regulatory context
Separate summaries for Great Britain, the United States, and the European Union. These are preliminary research summaries awaiting independent regional review; they are not legal determinations or advice.
Great Britain
Not a licensed medicine or approved supplement anywhere; a research chemical only, with essentially no human safety data. No legal human-use route exists.
This is preliminary regulatory research, not a reviewed legal determination or legal advice.
United States
Regional legal and regulatory review required before publication.
This is preliminary regulatory research, not a reviewed legal determination or legal advice.
- FDA's Concerns About Unapproved Drugs · U.S. Food and Drug Administration
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks · U.S. Food and Drug Administration
European Union
Regional legal and regulatory review required before publication.
This is preliminary regulatory research, not a reviewed legal determination or legal advice.
- Buying medicines online · European Medicines Agency
What the community says
Treated even within the nootropics community as one of the more experimental, 'proceed with real caution' compounds, largely because of how little human data exists.
Where they’re talking
- r/NootropicsFrequently flagged as highly experimental.
References
- 1.Supply unlicensed medicinal products (specials) · MHRA
- 2.FDA's Concerns About Unapproved Drugs · U.S. Food and Drug Administration
- 3.Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks · U.S. Food and Drug Administration
- 4.Buying medicines online · European Medicines Agency