Metabolic
HGH Fragment 176-191
AOD9604 precursor fragment · fragment · fat-targeting
The original growth-hormone fat-burning fragment that AOD-9604 was engineered from — mostly animal data, marketed for fat loss without significantly affecting blood sugar.
Reference status
Editorial research · independent review pending · 3 claims graded
What it is
This is the natural fragment of growth hormone thought to be responsible for its fat-metabolising effects, isolated from the parts responsible for GH's growth and blood-sugar effects. AOD-9604 is a modified, more stable version of essentially the same idea.
As with AOD-9604, the appeal is 'fat-burning without GH's downsides' — but human trial support for meaningful fat loss at community doses is thin, resting mostly on animal studies and the mechanism itself.
The science, graded
What’s claimed — and how strong the evidence behind each claim actually is.
“Burns fat without raising blood sugar”
Supported by animal fat-metabolism studies; the closely related AOD-9604 failed to beat placebo in its human obesity trial.
Claim-level citation mapping is in progress.
“Free of GH's growth-related side effects”
Consistent with the fragment's design rationale; not separately confirmed in large human trials.
Claim-level citation mapping is in progress.
“A proven human fat-loss agent”
The best related human trial data (for AOD-9604) did not support this claim.
Claim-level citation mapping is in progress.
Legal and regulatory context
Separate summaries for Great Britain, the United States, and the European Union. These are preliminary research summaries awaiting independent regional review; they are not legal determinations or advice.
Great Britain
Not a licensed medicine in the UK; a research chemical only, with no legal human-use supplement route.
This is preliminary regulatory research, not a reviewed legal determination or legal advice.
United States
Regional legal and regulatory review required before publication.
This is preliminary regulatory research, not a reviewed legal determination or legal advice.
- FDA's Concerns About Unapproved Drugs · U.S. Food and Drug Administration
European Union
Regional legal and regulatory review required before publication.
This is preliminary regulatory research, not a reviewed legal determination or legal advice.
- Buying medicines online · European Medicines Agency
What the community says
Often confused with or discussed interchangeably with AOD-9604 in forums — both share the same underlying evidence gap.
Where they’re talking
- r/PeptidesFrequently discussed alongside AOD-9604 with similar scepticism.
References
- 1.Supply unlicensed medicinal products (specials) · MHRA
- 2.FDA's Concerns About Unapproved Drugs · U.S. Food and Drug Administration
- 3.Buying medicines online · European Medicines Agency